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National Institutes of Health (NIH)
NIH SBIR Phase I (Parent R43/R44)
Amount
Up to $400,000
Deadline
Sep 5, 2026
Closes in 5 days
Odds
~15 to 20% funded
Can you get this?
✓US-based for-profit small business
✓500 employees or fewer
✓At least 51% owned by US citizens or permanent residents
✓Principal investigator primarily employed by the business
✓Business performs the majority of the research
Your real odds
NIH receives more than 3,500 Phase I applications in a typical year and funds roughly 15% of them.
Rates run lower still at the most competitive institutes, and NIH scores scientific merit and commercial potential separately, so a strong science case on its own does not carry an application.
What it takes
Register in SAM.gov, eRA Commons and Grants.gov2 to 4 weeks
Contact the SBIR program officer at your target institute30 min
Draft specific aims and the research plan10 to 12 weeks
Submit by 5 pm your organization's local time
Worth knowing
NIH advises that a competitive Phase I takes 10 to 12 weeks of focused work, and PA-27-100 routes a single application across 27 NIH institutes plus CDC and FDA centers, so choosing the right institute and speaking to its program officer before you write is the highest-leverage move you can make.
What else do you qualify for?
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